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| This page was last modified on Sunday, November 20, 2011 11:25:36 PM
Welcome to the Huang Lab at The Case Western Reserve University School of Medicine Principal Investigator Alex Y. Huang, MD, PhD University Hospitals Case Medical Center / Rainbow Babies & Children's Hospital Cleveland, Ohio USA | |
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Focus of our laboratory... Regulation between immune activation and tolerance is crucial in the pathogenesis of cancer. Recent development of intravital 2-photon microscopy allows direct observation of how immune cells traffic and interact with various cells in the tumor micro-environment in real time with single-cell resolution.
Our laboratory is interested in applying this and other classical immunological techniques to study various aspects of anti-tumor immune responses, immune – host – pathogen interaction, T cell-mediated memory immunity, and chemokine - receptor biology. Ongoing projects include: 1) Interrogation of the signaling crosstalk among molecular mediators downstream of the antigen receptor and chemokine receptors in T cells 2) Investigation into factors which influence the dynamic recruitment of T cells and their interactions with tumor cells and associated antigen-presenting cells in tumor-associated micro-environment 3) Imaging dynamic interaction between peri-vascular APC and Th17 cells in the CNS during early induction of acute experimental autoimmune encephalomyelitis 4) Discovering molecular signaling mechanisms responsible for the regulation of chemokine receptor expression on naive T cells 5) Testing the efficacy of genetically-modified tumor vaccines in the setting of sarcomas and other childhood cancer 6) Developing imaging techniques to interrogate immune cell migration and interactions in tissues such as the bone marrow, lung, kidney, GI track and the skin.
The long-term goal of our laboratory is to translate insights gained from basic investigations of in vivo immunity into rationally designed tumor vaccine and immunotherapeutic clinical trials, with a particular emphasis in the areas of pediatric sarcomas and other solid tumors.
Our lab / shipping address: Wolstein Research Building, Room 6402 2103 Cornell Road Cleveland, OH 44106-7288 (216) 368-0015 To locate the Wolstein Research Building and other buildings on campus, please visit:
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Recent Publications Germain RN, Bajenoff M, Castellino F, Chieppa M, Egen JG, Huang AYC, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 2008; 221:163-181 Tong C, Barkauskas D, Nthale J, Bays E, Su C, Liou H-L R, Huang AYC. Visualizing dynamice immune cell interaction and function with two-photon microscopy. Microsc Microanal 2008; 14:152-153. Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol. 2007, 28(8):346-52. Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martin-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin- CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 2007, 8(7):743-52. Huang AY. Watching Immune Cells in Action. Biology of Blood and Marrow Transplantation. 2007, 13:111-114. Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TCL engagement. J Exp Med. 2006, 203:2841-52. Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312-1672-76. Castellino F*, Huang AY*, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 2006, 440:890-95 (*shared first authorship). Bajenoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natureal killer cell behavior in lymph nodes revealed by static and real-time imaing. J Exp Med. 2006, 203:619-31. Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravita immune imaging. Semin Immunol. 2005, 17:431-41. Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 2004, 21:331-339. [for a complete list of publications, please see ABOUT US page]
| | Huang Lab in the NEWS...
July 2011 Congratulations to Dr. Agne Petrosiute, MD for being awarded the FRAP Career Development Award. This $40,000 award is given to one senior fellow-junior faculty each year in the Department of Pediatrics in support and recognition of his/her accomplishment in research. Congratulations, Agne!
June 2011 Congratulations to Youmna Othman, MD for being chosen as a recipient of the St. Baldrick's Fellow Scholarship through a competitive national grant review process for her proposal to monitor T cell ALL infiltration in the CNS through the Blood-Brain Barrier in a spontaneous murine leukemia model. This award is for a 2-year period in the amount exceeding $155,000.
June 2011 Dr. Alex Huang has just received an additional $230,000 grant from the St. Baldrick's Foundation for the laboratory's effort to define immune surveillance in pediatric sarcomas and other cancers.
April 2011 Congratulations to Deborah Barkauskas for being named the 2011 Distinguished Scholar Award in the upcoming Microscopy & Microanalysis 2011 meeting in Nashville, TN for her paper entitled, Monitoring Immune Cell Infiltration in the Brain with Intravital Two-Photon Microscopy. She will receive compensation to attend the annual meeting in August, and will present her research finding in T cell recruitment in EAE as a poster.
March 2011 The Huang lab has another spectacular year of fund-raising on behalf of the St. Baldrick's Foundation. Dr. Huang, Jay Myers, and Jennifer Tsai were part of the Rainbow Babies & Children's Hospital Team which raised a record $23,000+. Dr. Huang was among the top 10 personal fundraisers in the city of Cleveland, with more than $4700.
March 2011Congratulations to Jennifer Tsai, CWRU SOM for being named a St. Baldrick's Summer Fellow ffor her work in characterizing antigen presenting cell populations in the CNS of EAE mosue. The award is for a total of $5000 for one year.
August 2010 Congratulations to Youmna Othman, MD for being recognized as a 2010 Hyundai Research Award recipient sponsored by Hyundai Motors of America. Dr. Othman is the first fellow at Rainbow to receive this recognition which comes with a $50,000 grant to support  her research into understanding mechansims controlling lymphocyte migration across the blood-brain-barrier. In June 2010, Dr. Othman also received a $15,000 FRAP research award sponsored by the Rainbow Board to support her research endeavor in creating a model for intravital microscopy recording of lymphocyte migration in the spinal cord.
June, 2010 Congratulations to Agne Petrosute, MD for being chosen as a recipient of the St. Baldrick's Fellow Scholarship through a competitive national grant review process for her work in establishing a role for CDK5 in Medulloblastoma. The award is for a 2-year period in the amount exceeding $146,000. June 14, 2010 Congratulations to Kathryn Davis for being named one of only 6 recipients nationally of the inaugural St. Baldrick's Summer Fellow Grant. This pilot grant is designed to foster research interests in Pediatric Hematology-Oncology for future medical doctors.
June 8, 2010 Read an article about Dr. Huang in the latest issue of Inspiration 2010 - A Newsletter from Gabrielle's Angel Foundation for Cancer Research.
Dr. Huang was featured in the "Quote of the Month" section in the most recent newsletter from the St. Baldrick's Foundation...
A BIG Thank-You to...
all who helped champion the cause of finding a cure for Childhood Cancer through St. Baldrick's Foundation Head-shaving Fundraising Event in March! Team Rainbow had a fantastic year, being #1 fundrasing team in the Cleveland area totalling $18,893!!! with a record 17 shavees (including 4 from the Huang lab: Nile Chang, Jay Myers, Stefanos Intzes and Alex Huang). Alex Huang led team Rainbow with $4131. Huang lab members raised a combined $6257! Thanks to everyone for your generosity and for believing in our mission! Remember, There is still time to contribute through June. So click on the links in the article below (dated March 10, 2010) to help out this most worthy cause!
Remember to visit our sponsors page and support all the organizations and foundations that have helped us fulfilling our research mission! Thank you.
March 10, 2010 Here we go again....Alert! Alert! Alert! Alex will be shaving his head on St. Patrick's Day (March 17th, 2010) to raise awareness and funds for Pediatric Cancer as part of the St. Baldrick's Day Event!!! New is year is the news that Nile Chang and Jay Myers will also be joining in the head shaving party!!!! Please consider this noble cause and join us as partners in the fight against Childhood Cancer!!! For more info, click on the images above to find out and donate.
July, 2009 Congratulations to... Dr. Stefanos Intzes, MD and Dr. Agne Petrosiute, MD for being awarded $15,000 each as two of the 4 top-prize fellow recipients of the inaugural Fellows Research Award Program (FRAP) sponsored by the Rainbow Board and the Office of Pediatric Fellowship Directors. The awards are granted to promising young investigators in pursuit of an academic research career in Pediatrics. Both Drs. Intzes and Petrosiute are currently in the laboratory of Dr. Alex Huang. Dr. Intzes is studying the effect of host immune responses in osteosarcoma, while Dr. Petrosiute is studying the role of novel protein kinases in migration and metastasis of medulloblastoma, a common malignant childhood brain tumor. Way to go, Agne and Stefanos!
March 31st, 2009 Congratulations to... Deborah Barkauskas for being awarded scholarship funding from the Choose Ohio first Scholarship (COF) and James Fellowship. Great job, Deb!
March 17th, 2009 Okay, it's done! Thanks to all who have joined the fight against childhood cancer. Help spread the word around. St. Baldrick's Fund Raising does not end after today...It's not too late to donate... Donate now!
March 8th, 2009 Alert! Alert! Alert! I will be shaving my head on St. Patrick's Day (March 17th, 2009) to raise awareness and funds for Pediatric Cancer as part of the St. Baldrick's Day Event!!! My head shaving will take place LIVE on Cleveland's FOXNews 8 on March 19th, 2009 at 8:20am during the morning News show. Please consider this noble cause and join me as partners in the fight against Childhood Cancer!!! For more info, click on the images to find out and donate... February 24, 2009 Dr. Huang will be chairing a symposium session on intravital imaging  of tumor and associated microenvironment at the upcoming Microscopy & Microanalysis 2009 annual meeting in July 26-30, 2009 in Richmond, Virginia. For details regarding the meeting, please visit M&M2009 website. The session Dr. Huang will be chairing is B06: Intravital Imaging of Cancer and Associated Cellular Response.
October, 2008 Read the latest press release and Case Daily article regarding St. Baldrick's Scholar Award for the Huang lab...
August, 2008 August 19, 2008 Dr. Huang has been awarded the Hyundai Pediatric Research Scholar through Hyundai Motor America's "Hope on Wheels" program and the generous support of local Hyundai dealerships in the greater Cleveland area. The award was announced in a public ceremony attended by Corporate and Dealship representatives from Hyundai Motor America, UH/Rainbow representatives, and patients and families from Rainbow 2. Be sure to support this great program from Hyundai, " Hope on Wheels."
June, 2008 Dr. Huang has just been granted a 3-year Career Development Award from the St. Baldrick's Foundation to study immunotherapy and tumor-immune interaction in Pediatric Sarcomas. Detail news to come...
June, 2008 Huang lab has just been profiled in the Cancer Research Institute (New York, NY) Website:
June, 2008 Read a profile of Dr. Huang and his research into Multiple Sclerosis at The Dana Foundation Website:
Huang lab mentioned in the first edition of the Rainbow-Ireland Newsletter...
Congratulations to Emi Bays for being recognized by CWRU for her outstanding poster presentation at the Lepow Day Research Symposium on January 10, 2008. Good Job, Emi!
December 7, 2007: School of Medicine researcher pioneers new technology in study of life-threatening liinesses In researching diseases scuh as cancer and multiple sclerosis, immunologists mostly have had to observe static immune cells in laboratories -- until now. Alex Huang, a pediatric oncologist with the Department of Pediatrics at Case Western Reserve University School of Medicine...
July 30, 2007: Double Research Grant Award Case Case Comprehensive Cancer Center Newsletter Young Cancer Center Investigator Awarded Two Research Grants Congratulations to Dr. Alex Huang, Assistant Professor of Pediatric Hamtology / Oncology at CWRU / UH who is the recent recipient of two prestigious research grants...
Links to related sites University Hospitals: Rainbow Babies & Children's Hospital:
Ireland Cancer Center:
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