The Huang Laboratory of In Vivo Immune Migration & Interaction

Discover Immunity in Health & Disease.... Find a Cure for Childhood Cancer.

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This page was last modified on Monday, June 01, 2009 11:54:56 AM


                                                                                                                      
  
 
 
                                                     
 
Welcome to
 
The Huang Lab
  at
Case Western Reserve University
 
Principal Investigator:
 
Alex Y. Huang, MD, PhD 
                  
University Hospitals Case Medical Center / Rainbow Babies & Children's Hospital
    
Focus of our laboratory...
 
Regulation between immune activation and tolerance is crucial in the pathogenesis of cancer. Recent development of intravital 2-photon microscopy allows direct observation of how immune cells traffic and interact with various cells in the tumor microenvironment in real time with single-cell resolution.

Our laboratory is interested in applying this and other classical immunological techniques to study various aspects of anti-tumor immune responses, immune – host – pathogen interaction, T cell-mediated memory immunity, and chemokine - receptor biology.  Ongoing projects include:
 
1) Interrogation of the signaling crosstalk among molecular mediators downstream of the antigen receptor and chemokine receptors in T cells
 
2) Investigation into factors which influence the dynamic recruitment of T cells and their interactions with tumor cells and associated antigen-presenting cells in tumor-associated microenvironment
 
3) Imaging dynamic interaction between peri-vascular APC and Th17 cells in the CNS during early induction of acute experimental autoimmune encephalomyelitis
 
4) Discovering molecular signaling mechanisms responsible for the regulation of chemokine receptor expression on naive T cells
 
5) Testing the efficacy of genetically-modified tumor vaccines in the setting of sarcomas and other childhood cancer
 
6) Developing imaging techniques to interrogate immune cell migration and interactions in tissues such as the bone marrow, lung, kidney, GI track and the skin.     

The long-term goal of our laboratory is to translate insights gained from basic investigations of in vivo immunity into rationally designed tumor vaccine and immunotherapeutic clinical trials, with a particular emphasis in the areas of pediatric sarcomas and other solid tumors.                                
 

 

Our lab / shipping address:

 

Wolstein Research Building, Room 6402

2103 Cornell Road

Cleveland, OH 44106-7288

(216) 368-0015

 

To locate the Wolstein Research Building and other buildings on campus, please visit:

 


Support our sponsors
 

 


 

Recent Publications
 
 
Germain RN, Bajenoff M, Castellino F, Chieppa M, Egen JG, Huang AYC, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 2008; 221:163-181
 
Tong C, Barkauskas D, Nthale J, Bays E, Su C, Liou H-L R, Huang AYC. Visualizing dynamice immune cell interaction and function with two-photon microscopy. Microsc Microanal 2008; 14:152-153.
 
Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol. 2007, 28(8):346-52.
 
Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martin-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin- CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 2007, 8(7):743-52.
 
Huang AY. Watching Immune Cells in Action. Biology of Blood and Marrow Transplantation. 2007, 13:111-114.
 
Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TCL engagement. J Exp Med. 2006, 203:2841-52.
 
Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312-1672-76.
 
Castellino F*, Huang AY*, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 2006, 440:890-95 (*shared first authorship).
 
Bajenoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natureal killer cell behavior in lymph nodes revealed by static and real-time imaing. J Exp Med. 2006, 203:619-31.
 
Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravita immune imaging. Semin Immunol. 2005, 17:431-41.
 
Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 2004, 21:331-339.
 
[for a complete list of publications, please see ABOUT US page]

Huang Lab in the NEWS...

March 17th, 2009
Okay, it's done!
 
Thanks to all who have joined the fight against childhood cancer. Help spread the word around. St. Baldrick's Fund Raising does not end after today...It's not too late to donate...Donate now!
 

March 8th, 2009 
Alert! Alert! Alert!
I will be shaving my head on St. Patrick's Day (March 17th, 2009) to raise awareness and funds for Pediatric Cancer as part of the St. Baldrick's Day Event!!! My head shaving will take place LIVE on Cleveland's FOXNews 8 on March 19th, 2009 at 8:20am during the morning News show.
 
Please consider this noble cause and join me as partners in the fight against Childhood Cancer!!! For more info, click on the images to find out and donate...
 
 
 
February 24, 2009
 
Dr. Huang will be chairing a symposium session on intravital imaging of tumor and associated microenvironment at the upcoming Microscopy & Microanalysis 2009 annual meeting in July 26-30, 2009 in Richmond, Virginia. For details regarding the meeting, please visit M&M2009 website. The session Dr. Huang will be chairing is B06: Intravital Imaging of Cancer and Associated Cellular Response.
 
Please consider attending this annual meeting. Visit: Registration information.

October, 2008
 
Read the latest press release and Case Daily article regarding St. Baldrick's Scholar Award for the Huang lab...
 
 
 

August, 2008
 
Huang lab has just been awarded a 3-year Medical Research Award from Gabrielle's Angel Foundation for Cancer Research (formerly the G&P Foundation for Cancer Research).
 
 

August 19, 2008
 
Dr. Huang has been awarded the Hyundai Pediatric Research Scholar through Hyundai Motor America's "Hope on Wheels" program and the generous support of local Hyundai dealerships in the greater Cleveland area. The award was announced in a public ceremony attended by Corporate and Dealship representatives from Hyundai Motor America, UH/Rainbow representatives, and patients and families from Rainbow 2. Be sure to support this great program from Hyundai, "Hope on Wheels."
 

June, 2008
 
Dr. Huang has just been granted a 3-year Career Development Award from the St. Baldrick's Foundation to study immunotherapy and tumor-immune interaction in Pediatric Sarcomas. Detail news to come...
 

June, 2008
 
Huang lab has just been profiled in the Cancer Research Institute (New York, NY) Website:
 

June, 2008
 
Read a profile of Dr. Huang and his research into Multiple Sclerosis at The Dana Foundation Website:
 

Huang lab mentioned in the first edition of the Rainbow-Ireland Newsletter...
 

Congratulations to Emi Bays for being recognized by CWRU for her outstanding poster presentation at the Lepow Day Research Symposium on January 10, 2008.
 
Good Job, Emi!

December 7, 2007:
 
School of Medicine researcher pioneers new technology in study of life-threatening liinesses
 
In researching diseases scuh as cancer and multiple sclerosis, immunologists mostly have had to observe static immune cells in laboratories -- until now. Alex Huang, a pediatric oncologist with the Department of Pediatrics at Case Western Reserve University School of Medicine...
 

July 30, 2007:
 
Double Research Grant Award Case
Case Comprehensive Cancer Center Newsletter
 
Young Cancer Center Investigator Awarded Two Research Grants
Congratulations to Dr. Alex Huang, Assistant Professor of Pediatric Hamtology / Oncology at CWRU / UH who is the recent recipient of two prestigious research grants...
 
 


 
Links to related sites
 
University Hospitals:
 
Rainbow Babies & Children's Hospital:
 
Ireland Cancer Center: